Buy Prednisone for Asthma: Reducing Inflammation in the Airways Prednisone is often prescribed to manage asthma flare-ups, especially when other treatments like inhalers are not effective enough. It works by reducing inflammation in the airways, making it easier to breathe and preventing severe asthma attacks. While prednisone can be lifesaving during an acute asthma attack, its long-term use can lead to side effects like weight gain, mood swings, and high blood sugar, so it is typically used as a short-term solution.