Xanax and Tramadol are two of the most commonly prescribed medications in the United States. It has a boxed warning from the FDA, which alerts doctors and patients to the risk of dependence and addiction. Both are powerful drugs that can help with various conditions. However, the drugs can be dangerous if used together. Taking Xanax and tramadol together can have deadly effects, including extreme sedation and unresponsiveness, severe respiratory depression, coma, and death.