In the realm of pharmaceuticals, understanding the potential risks associated with mixing medications is paramount. Duratia, a medication primarily used to treat premature ejaculation, is no exception. While Duratia can offer relief for those struggling with this condition, its interaction with other substances can pose significant dangers. This article explores the potential hazards of combining Duratia with alcohol, prescription medications, and recreational drugs. There have been reports of adverse reactions and consequences associated with mixing Duratia with other substances. Individuals have experienced severe side effects, including serotonin syndrome and respiratory depression, requiring emergency medical intervention. These incidents highlight the importance of understanding the risks and potential consequences of combining Duratia with other substances.