In the world of anabolic steroids, few compounds are as legendary, powerful, and polarizing as Oxymetholone, better known as Anadrol. Originally developed for legitimate medical purposes, Anadrol has since become a cornerstone in the bodybuilding, powerlifting, and strength performance communities.

Whether you’re a curious beginner or an experienced lifter looking to optimize your stack, this comprehensive guide will explore what Oxymetholone is, how it works, its benefits, risks, and how to use it safely and effectively.

🔬 What is Oxymetholone?

Oxymetholone is a synthetic anabolic steroid first introduced in the 1960s by Syntex under the brand name Anadrol-50. It was initially used to treat:

Severe anemia

Osteoporosis

Muscle wasting diseases (cachexia)

Growth disorders in underdeveloped children

Over time, it gained traction in the fitness and bodybuilding world due to its extraordinary ability to rapidly increase muscle mass and strength in short cycles.

⚙️ How Oxymetholone Works in the Body

Oxymetholone mimics the effects of testosterone, the body’s primary male sex hormone. It enhances the body's anabolic processes, specifically:

Increasing red blood cell count – boosting oxygen delivery to muscles

Enhancing nitrogen retention – a critical element for muscle repair

Accelerating protein synthesis – enabling rapid muscle recovery and growth

Improving muscle glycogen storage – leading to larger, fuller muscles

Despite not aromatizing (converting to estrogen), Oxymetholone exhibits estrogen-like side effects such as bloating and gynecomastia. This is likely due to its progestogenic activity or indirect estrogen receptor interaction.

📈 Anabolic/Androgenic Ratings

Anabolic Rating: 320 (Highly Anabolic)

Androgenic Rating: 45 (Moderate)

This means Oxymetholone is over three times more anabolic than testosterone while being significantly less androgenic — making it incredibly effective at building muscle without extreme masculinizing side effects (though they still exist in higher doses or prolonged use).

🧠 Oxymetholone vs. Other Steroids

Compound

Anabolic Rating

Androgenic Rating

Ideal Use

Oxymetholone

320

45

Bulking, Strength

Dianabol

90–210

40–60

Bulking, Strength

Testosterone

100

100

All-purpose

Winstrol

320

30

Cutting, Hardness

Anavar

322–630

24

Cutting, Recomp

✅ Benefits of Oxymetholone (Anadrol)

1. Explosive Muscle Mass Gains

Anadrol is famous for helping users gain 5–10 kg of weight in under 4 weeks. While some of this is water, a significant amount is lean muscle mass, especially in early stages of a cycle.

2. Boosts Strength and Power Output

Powerlifters love Anadrol for its dramatic increases in strength. Expect PRs (personal records) in nearly every lift when dosed correctly.

3. Rapid Results

Unlike injectables that take time to build up in your system, Oxymetholone kicks in within the first week, making it ideal for jumpstarting a bulking cycle.

4. Improved Muscle Fullness and Pumps

Due to glycogen retention and water uptake in the muscles, Anadrol makes your physique appear fuller and more vascular (if body fat is low enough).

5. Enhanced Red Blood Cell Production

Increased oxygenation allows for longer, more intense workouts, faster recovery, and reduced fatigue.

📉 Side Effects of Oxymetholone

Despite its effectiveness, Oxymetholone is known for its notable side effects, especially if misused.

🚨 Common Side Effects:

Water retention & bloating

Liver toxicity (hepatotoxic)

Gynecomastia (man boobs)

High blood pressure

Suppressed natural testosterone production

Mood swings, irritability

Acne & hair loss (especially in those genetically prone)

⚠️ Liver Toxicity Warning:

Oxymetholone is a C-17 alpha-alkylated steroid, which means it’s modified to survive oral ingestion but is harsh on the liver.

🛡️ Protect your liver with TUDCA, NAC, or milk thistle during the cycle.

📆 How to Use Oxymetholone (Cycle Guidelines)

🔹 Beginner Bulking Cycle Example:

Week 1–4: Oxymetholone – 25–50mg/day

Week 1–12: Testosterone Enanthate – 500mg/week

Week 1–12: Aromatase Inhibitor (Arimidex) – 0.5mg EOD

Week 13–16: PCT (Nolvadex + Clomid)

🔹 Intermediate Cutting Stack (Advanced Users):

Week 1–4: Oxymetholone – 25mg/day

Week 1–6: Masteron – 400mg/week

Week 1–6: Testosterone Propionate – 100mg EOD

Optional: Winstrol or Tren for added hardness

AI as needed + liver support

Note: Not recommended to run Anadrol for more than 4–6 weeks due to its hepatotoxic nature.

⚠️ Do You Need PCT After Oxymetholone?

Yes. Anadrol severely suppresses natural testosterone. Always run a Post Cycle Therapy (PCT) including:

Clomid: 50mg/day (2 weeks)

Nolvadex: 40/20/20 mg per day for 3–4 weeks

Natural Test Boosters: Zinc, D-aspartic acid, Ashwagandha

👥 Who Should Use Oxymetholone?

Experienced lifters looking for explosive mass and power

Powerlifters or strongmen wanting short-term performance boosts

Competitive bodybuilders (in very controlled settings)

Not recommended for beginners, women, or anyone with pre-existing liver or cardiovascular issues

📊 Scientific Evidence and Studies

Study on HIV-related muscle wasting showed significant lean mass gains in patients using Oxymetholone.

Controlled trials have also observed improved nitrogen retention and increased hemoglobin levels, confirming its strength-building potential.

📚 Source: J Clin Endocrinol Metab. 2003

🤔 Can Oxymetholone Be Used for Cutting?

While it's typically used for bulking, many advanced athletes use Anadrol during a cut to preserve muscle and maintain strength while dieting.

Read this full guide:
 

👉 Is Anadrol Good for Cutting?

🧱 Oxymetholone Stacking Options

Stack Goal

Other Compounds to Include

Bulking

Testosterone, Deca-Durabolin, Dianabol

Strength

Trenbolone, Test Propionate, Halotestin

Cutting

Masteron, Winstrol, Anavar

Recomp

EQ, Tren, Test

📌 Where to Learn More or Buy Anadrol (Oxymetholone)

If you’re looking for safe, trusted guides and access to performance-enhancing compounds, visit:
👉 TheCityPlug1.com
Read more on Anadrol:
🔗 Anapolon Oxymetholone 50mg – Full Guide
🔗 Oxymetholone 50 mg Benefits

❓ FAQs About Oxymetholone

Is Oxymetholone legal?

In many countries, it’s classified as a controlled substance. It's legal with a prescription in some medical settings but banned in most athletic competitions.

What’s the best Oxymetholone dosage?

For most, 25–50mg per day is optimal. Higher doses increase risk without significantly better gains.

Can women use Anadrol?

No. Due to its strong androgenic effects, women risk virilization (deep voice, hair growth, etc.)

How long does it stay in your system?

The half-life is ~9 hours, but metabolites can be detected for weeks after last dose.

🧾 Final Thoughts: Is Oxymetholone Worth It?

Oxymetholone is not a casual compound. It's powerful, fast-acting, and capable of delivering exceptional results, but only when used with caution and experience.

If you're serious about mass, strength, and performance, and you understand the risks, Anadrol can be a game-changer.

But respect the process. Use liver protection, monitor your health, and never skip PCT.

🧭 Want to Learn More?

Start with these essential guides from The CityPlug:

📘 Oxymetholone 50mg Benefits

📘 Anapolon Oxymetholone 50mg Review

📘 Anadrol for Cutting